Machiela et al. demonstrated that adeno-associated virus (AAV) transduction of progerin in iPSC-derived NPCs resulted in increased damage in differentiated HD cells but not controls, although both the differentiated control and HD cells exhibited reduced dendritic lengths and similar caspase activation when transduced with progerin as iPSC-derived NPCs [31]. The gene discussed is LMNA; the disease is Huntington disease.