APOE and Alzheimer disease: (b) Olfactory bulb AD and PD pathology, along with olfaction deficits, are reported in MMC children and young adults and remarkably, Apolipoprotein E allele 4 carriers (APOE4) are 4.57 times more likely to die by suicide versus APOE 3 carriers, and have higher chances of exhibiting olfactory bulb neuronal alpha-synuclein aggregates and hyperphosphorylated tau neurites and tangles [8,47].