POGZ and obesity due to melanocortin 4 receptor deficiency: In 2016, White et al. referred for the first time to POGZ variants as a cause of syndromic ID, describing five individuals with disruptive variants in POGZ and expanding the phenotype previously reported by Ye et al. with additional clinical features: motor coordination problems, ocular manifestations, hyperactivity, tendency to obesity, and feeding difficulties [2].