The relationship between sensory polyneuropathy and POGZ variants is not totally unexpected for two reasons: (1) Campo et al. identified POGZ as a susceptibility gene for Bortezomib-induced Peripheral Neuronopathy [34], and (2) L1CAM, whose variants associate with congenital hydrocephalus, adducted thumbs, and spasticity, is differentially expressed in POGZ-deficient cell lines, indicating a functional interaction between the two genes [33]. This evidence concerns the gene POGZ and congenital hydrocephalus.