In this work, we aimed to study the consequences of the modulation of the PTN/RPTPβ/ζ signaling pathway and its possible influence in neuron-microglia communication using a well-studied acute MPP+ in vitro model of PD, the endogenous inhibitor of RPTPβ/ζ, PTN, and the selective small-molecule inhibitor of RPTPβ/ζ, MY10. This evidence concerns the gene PTPRZ1 and Parkinson disease.