LOX and neoplasm: The lysyl oxidase family members are secreted copper-dependent oxidases, including five paralogues: LOX, LOX-like 1–4 (LOXL1–4), which act to exert catalytic activity to remodel the cross-linking of the extracellular matrix (ECM) of fibrotic liver and that of a corrupted tumor microenvironment (TME) [4].