The analysis of mutations in 22 specific cMS genes revealed a significantly higher proportion of mutant alleles in two genes, LMAN1 (0.29 vs. 0.11, p = 0.038) and ELAVL3 (0.37 vs. 0.17, p = 0.009), and a significantly lower proportion of mutant alleles in one of the analyzed cMS located in the RFC3 (0.03 vs. 0.19, p = 0.011) gene in incident cancers compared to prevalent ones (Figure 4E, Supplementary Figure S3). This evidence concerns the gene RFC3 and cancer.