When focusing on indel APC mutations alone, a significantly higher proportion of mutations was found in incident CRC compared to prevalent CRC in LS patients (64.3 vs. 16.7%, 95% CI: 38.6–83.8 and 7.5–32.3%, respectively; p = 0.0068, Figure 3C,E). The gene discussed is APC; the disease is colorectal carcinoma.