LMAN1 and cancer: By applying the ReFrame algorithm as a highly sensitive method to detect and quantify specific cMS mutations [45], we were able to detect significant differences in mutation frequency for three individual cMS between incident and prevalent cancers: two cMS genes, LMAN1 and ELAVL3, showed significantly higher mutation frequencies in incident compared to prevalent cancers, whereas the RFC3 cMS gene showed a significantly lower mutation frequency, thereby notably showing changes in mutation frequencies in both directions.