ACE2 and COVID-19: Some indirect evidence suggests that one of the key causes of increased mortality rates in high-risk patients with COVID-19 is the lower expression and inactivation of ACE-2/Mas/Ang in the cardiovascular system, resulting in the activation of the JNC/Bcl-2-Beclin1 or JNC/Bcl-2-Bax signaling pathways and the initiation of autophagy or apoptosis.