APOA1 and hepatocellular carcinoma: In line with these studies by Kaptein et al., Malle et al. confirmed in HUH-7 hepatoma cells that 2 mM butyrate increased the intracellular ApoA-I protein synthesis by three-fold after 48 h, whereas ApoA-I secretion was 2.5 times higher compared to the control [52,53,54].