Recently, Du et al. has shown that DHA induces autophagy of leukemia cells partly by inhibiting p-mTOR, p-S6K1, and p-S6 and activating p-AMPK in leukemia (HL60 and THP-1) cells [26], but whether DHA-induced mTORC1 inhibition is a consequence of AMPK activation has not been resolved. The gene discussed is PRKAA1; the disease is leukemia.