YTHDF2 and renal carcinoma: Depletion of YTHDF2 in iSLK.BAC16 cells, a renal carcinoma cell line infected by recombinant KSHV BAC16, led to enhanced KSHV replication and increased half-lives of viral transcripts, suggesting an anti-viral role for YTHDF2, while the other YTHDF readers did not consistently affect KSHV replication [117].