Its binding to miR-377-3p in bladder cancer cells leads to elevated expression of ZEB2. ZEB2 is implicated in the repression of E-cadherin (CDH1) and thus promotes TGF-β-dependent EMT [148], as the downregulation of the adhesion molecule E-cadherin is necessary for this process. This evidence concerns the gene ZEB2 and urinary bladder carcinoma.