In papillary thyroid cancer, circ-ITCH sponges miR-22-3p, leading to higher expression rates of its direct target, CBL. CBL is an E3 ubiquitin-protein ligase, which targets the active β-catenin and triggers its degradation, resulting in the inactivation of the WNT/β-catenin pathway [54]. This evidence concerns the gene CBL and thyroid gland papillary carcinoma.