Notably, the opposite was found in skin lesions from sD3KO mice (in which the TH inactivator enzyme D3 is genetically depleted and thyroid action is enhanced); indeed, VEGF-A and CD31 expression was higher than in D3WT tumors, which confirms that TH boosts tumor angiogenesis (Figure S5A,B). This evidence concerns the gene VEGFA and neoplasm.