Next, we assessed if VEGF-A is a direct target of TH in SCC cells by performing a chromatin immunoprecipitation (ChIP) assay, which confirmed that the TH TRα receptor physically binds VEGF-A in the human skin squamous cell carcinoma cells (SCC 13) (Figure 1F,G). The gene discussed is VEGFA; the disease is skin squamous cell carcinoma.