Strikingly, besides lung, authors further showed that SR-BI is co-expressed with ACE2, predominately in lower respiratory tissues that are more affected by COVID-19 and in several extrapulmonary tissues as retina, testis, as well as kidney which could indicate an extended trophism for extrapulmonary tissues, thereby to the multiple-organ pathologies of COVID-19 [175]. This evidence concerns the gene ACE2 and COVID-19.