A minor apolipoprotein found in HDL is the apolipoprotein M (ApoM) that transports the Sphingosine 1-phosphate (S1P), a lysophospholipid mediator involved in several physiological functions such as cellular proliferation and survival, endothelial nitric oxide synthase (eNOS) activation, and inhibition of inflammation and endothelial dysfunction [33]. The gene discussed is NOS3; the disease is endothelial dysfunction.