TIMELESS and cancer: In one pancreatic ITPN, heterogeneous deletion of the whole chromosome was observed, encompassing a region that contains numerous cancer-specific genes, including the classical cancer genes KRAS, MDM2, ARID2, KDM5A, TIMELESS, and WNT. Chromosome 14 revealed deletions in 53% of all analyzed ITPN samples, and 24% of these samples showed a complete heterogeneous chromosomal arm loss (position 20 to 92 MB).