It has also been reported that the activation of the neuronal P2X7-PANX1 axis mediates the death of enteric neurons during colitis [25], while the activation of the P2X7-PANX1 complex enhances spreading depolarization and neuroinflammation [9] of the trigeminovascular system, leading to migraine and stroke. The gene discussed is P2RX7; the disease is colitis.