SERPINE1 and cancer: In particular, it is included in EVs secreted by cancer-initiating cells (CICs) and stimulates migration and invasion through overexpression of plasminogen activator inhibitor 1 (PAI-1), metalloprotease (MMP), and tissue inhibitor of metalloproteases 1 (TIMP-1), but also promotes anchorage-independent growth and apoptosis resistance of PC recipient cells [97].