Furthermore, as an integral part of the TME and a large producer of the ECM, cancer associated fibroblasts (CAFs) release IL6, chemokine (C-C motif) ligand 2, and C–X–C motif chemokine ligand 12 (CXCL12) that eventually support tumor growth and metastases [126,127,128]. The gene discussed is IL6; the disease is neoplasm.