To examine whether the protective effect of HIF-1α after stroke is achieved by modulating inflammation, we evaluated the expression levels and mRNA of pro-inflammatory cytokines (iNOS, TNF-α, NF-κB and p-IκBα/IκBα), and anti-inflammatory cytokines (IL-10) in the ischemic brain. The gene discussed is NFKBIA; the disease is Stroke.