Examples of tumor suppressor proteins are retinoblastoma protein (RB1), tumor protein p53 (TP53), B-cell leukemia/lymphoma 2 (BCL2), breast cancer 2 (BRCA2), etc. Inactivated Rb is involved in carcinomas of the bladder, breast, and lung. The gene discussed is BRCA2; the disease is urinary bladder carcinoma.