Indeed, high BDNF expression has been detected in the atheromatous intima and adventitia of atherosclerotic arteries, as well as in smooth muscle cells, macrophages, and fibroblasts of human and mouse atherosclerotic plaques [19], suggesting a potential role of BDNF in coronary atherosclerosis progression and plaque activation and instability. This evidence concerns the gene BDNF and coronary atherosclerosis.