The difference was maintained in SA group also after adjustment for prior cardiovascular treatment (p < 0.026) and risk factors (p < 0.015), whereas it was lost in AMI groups after adjustment for diabetes (p = 0.221), hypertension (p = 0.083) and β-blockers (p = 0.052), but was maintained after adjustment for smoke, family history of CAD and dyslipidemia (p < 0.044) as well as for prior ACE-inhibitor, Statin and Aspirin treatment (p < 0.038). The gene discussed is ACE; the disease is diabetes mellitus.