MAP2K5 and obesity due to melanocortin 4 receptor deficiency: Additionally, rs16951275 is in high linkage disequilibrium with rs2241423 (R2 = 0.98), another variants in the MAP2K5 gene that has been linked repeated to obesity-related traits in adults and children [41,42], and rs16951275 has been shown to regulate gene expression of MAP2K5 in several tissues, including subcutaneous and visceral adipose tissue [43].