A careful analysis conducted in solid tumors (i.e., lung cancers [105]) highlighted a role in the YAP-mediated tumorigenesis and metastasis to the downregulation of LATS1/2 and AMOT proteins, to the aberrant expression of ABL kinases, the inactivation of either liver kinase B1 (LKB1), identified to suppress YAP action [106], or Ski, whose promoter becomes hypermethylated [107]. The gene discussed is STK11; the disease is lung carcinoma.