Similar to pancreatic carcinoma, in prostate cancer, YAP activation also promotes the secretion of a protumorigenic chemokine, C-X-C motif chemokine ligand 5 (CXCL5), which is responsible for Cxcl5–Cxcr2-mediated MDSC recruitment, thus impeding T cell proliferation [165]. This evidence concerns the gene CXCL5 and Familial prostate cancer.