CD274 and neoplasm: Specifically, the expression of YAP and TAZ by tumor cells has a direct effect on TILs, TAMs, and myeloid-derived suppressor cells (MDSCs) and regulates the expression of programmed death ligand 1 (PD-L1; also known as CD274), which binds to PD-1, a type I transmembrane protein expressed on activated T cells, B cells, monocytes, NK cells, and DCs [154] (Figure 2).