In this study, we identified four miRNAs (miR-34c-5p, miR-221-3p, miR-222-3p and miR-3529-3p) associated with reduced VEGFR1 and/or VEGFR2 expression and with tumor shrinkage and PFS upon treatment with VEGFR-TKIs, indicative of the potential predictive value of these miRNAs. Here, KDR is linked to neoplasm.