We identified four miRNAs (miR-34c-5p, miR-221-3p, miR-222-3p and miR-3529-3p) inversely correlated with VEGFR1 and/or VEGFR2 expression and associated with less tumor shrinkage and shorter PFS upon treatment with VEGFR-TKIs. This evidence concerns the gene KDR and neoplasm.