Angiogenesis inhibitors such as VEGF receptor tyrosine kinase inhibitors (VEGFR-TKIs) revolutionized the treatment of metastatic ccRCC (m-ccRCC) in 2006 [3] and remain an essential component of current management strategies, both in combination with immuno-oncology first-line therapies or as single agents in further treatment lines. This evidence concerns the gene KDR and nonpapillary renal cell carcinoma.