Pharmacological inhibition of TLR4 with eritoran or other inhibitors has been investigated in several acute liver injury models, including ischemia-reperfusion [20], trauma/shock [21] and acute-on-chronic liver failure models [34], which showed that TLR4 antagonists could suppress TLR4 signaling, the subsequent inflammatory cascade and liver injury in vivo. Here, TLR4 is linked to chronic liver failure.