ACE and type 1 diabetes mellitus: A review of 15 randomized controlled studies supports the beneficial effect of lowering the blood pressure in prevention of DR for up to 4–5 years [27], and there are suggestions that, in T1D patients, antihypertensive drugs (ACE-inhibitor) could be useful even in the presence of normotension (50% reduction in progression of retinopathy by at least one level, and with the lisinopril therapy for proliferative retinopathy the odds ratio was 0.18) [28].