The preponderance of the results indicates that NOTCH2, NOTCH3, and DLL4 are potential drivers of Notch signaling in BCa, playing the most crucial role in the progression and development of BCa via modulating the cell cycle and stemness, as well as direct or indirect interactions with well-known cancer-related pathways such as p53, TSC/mTOR, RAS/MAPK, and PI3K/AKT. Here, NOTCH2 is linked to cancer.