The ability of TGF-β to induce EMT is a crosstalk with ROS: ROS synergize with TGF-β both in the initiation and progression of cancer via EMT, not only by increasing the redox imbalance in tumor cells, but also by co-inducing EMT, which is then hyperactivated in carcinoma cells [74]. The gene discussed is TGFB1; the disease is carcinoma.