These secondary plant metabolites have the capacity to inhibit activity of carbohydrate hydrolyzing digestive enzymes, modulate the glucose transport, stimulate insulin secretion from pancreatic β-cells, reduce insulin resistance, increase insulin sensitivity, inhibit the activity of protein tyrosine phosphatase, reduce the production of protein glycation products, and improve antioxidant defenses [15,21,22,23]. Here, INS is linked to Insulin resistance.