This review outlines what is presently known about the role of the MCP families Gla-containing proteins (periostin, βigh3, matrix Gla protein), CCN, thrombospondin, SPARC, SIBLINGs, and tenascin in orofacial and dental tissue development, wound healing and neoplastic disease, and mechanisms involved in their regulation. This evidence concerns the gene POSTN and neoplasm.