CCN4 and neoplasm: Later, the same research group found that tumour secreted WISP-1/CCN4 promotes angiogenesis in oral SCC by upregulating VEGF-A via the αvβ3/FAK/c-Src pathway, which transactivates the EGFR/ERK/HIF1-α signalling pathway in oral SCC cells and increases angiogenesis-related tumour growth in vivo [156].