MAP3K5 and neoplasm: Wingless/Integrated-1(WNT1)-inducible signalling pathway protein 1(WISP-1)/CCN4 induces migration in oral SCC cells by ICAM-1 upregulation via αvβ3 integrin, ASK1, JNK/p38, and AP-1 signalling pathways, and its overexpression is strongly associated with advanced tumour stage [154], tumour progression and treatment failure [155].