Further, WISP-1/CCN4 promotes VEGF-C dependent lymphangiogenesis by inhibiting miR-300 (3′-UTR binding repressor of VEGF-C) in vitro via the integrin αvβ3/integrin-linked kinase (ILK)/Akt signalling pathway [157], and it has been suggested as a potential biomarker for predicting lymph node metastasis [158]. This evidence concerns the gene CCN4 and metastatic malignant neoplasm in the lymph nodes.