In our investigations, a comparative gene expression analysis revealed that the sorted CD44+ OSCC CSCs possess higher gene expression of CSC-related genes CD44 and CD133, stemness-related genes OCT4 and SOX2, EMT-related genes TWIST and NCAD, along with lower expression of epithelial gene ECAD than heterogeneous tumor cell population. The gene discussed is SOX2; the disease is neoplasm.