The risk factors identified by each prior study of this disorder have been different, but the following variables have been suggested to be associated with poor outcomes: severe encephalopathy, hypertensive etiology, hyperglycemia, neoplastic etiology, longer time to control the causative factor, presence of multiple comorbidities, elevated CRP, low CSF glucose, coagulopathy and brain MRI findings of corpus callosum involvement, extensive cerebral edema or worsening imaging severity, hemorrhage, subarachnoid hemorrhage and restrictive diffusion [22]. This evidence concerns the gene CRP and Encephalopathy.