Cytotoxic activity of the alkaloids 3-oxocoronaridine and 5-oxocoronaridine is also reported against SKBR-3 breast adenocarcinoma and C-8161 human melanoma tumor cell lines, this may be due to the interaction of these molecules with proteins involved in the PI3K/AKT pathways such as it has been explained extensively in this study. The gene discussed is AKT1; the disease is breast adenocarcinoma.