Voacangine, voacristine and isovoacristine have shown cytotoxicity against ovarian cancer (A2780 cell line), according to our computational analyzes both have affinity with AKT1 and GSK3 proteins with averages of −9.3 kcal/mol, which showed PPIs associated with endometrial cancer signaling pathways. The gene discussed is AKT1; the disease is ovarian cancer.