IL6ST and systemic lupus erythematosus: In our study, the level of the LSA/TSA ratio had higher values in SLE compared to control, and significantly lower values in LN compared to control and LSA correlated with IL-6, respectively, sIL-6R/sgp130, which denotes a link between glycosphingolipids catabolism and IL-6 trans-signaling in SLE.