A number of diseases associated with AGA have been reported: anti-GM1, anti-GD1b, anti-GQ1b IgM strongly correlated with Alzheimer’s disease, anti-GM3 and anti-GQ1b associated with multiple sclerosis, anti-GM1 with SLE, anti-GM1 or GM1-gliadin complexes with celiac disease, anti-GM2, anti-GD1a, anti GQ1b IgM isotype with HIV infection, anti-GD1b with parvovirus, anti-GM1, anti-GM2, anti-GM3, anti-GD1b, anti -GD1a with type I diabetes, anti -GM1, anti-sulfatide with Sjogren’s syndrome, rheumatoid arthritis, SLE and systemic vasculitis [17,32,34,35,36,37,38,40,41,42,43,44,52,53]. The gene discussed is CD40LG; the disease is multiple sclerosis.