SOD1 and Tinnitus: When several antioxidative substances (multivitamin and lipoic acid), which are effective against tinnitus in animal studies, were applied to patients with chronic tinnitus, the intensity and loudness of tinnitus decreased, but objective markers, such as total antioxidant capacity (TAC), SOD, and oxidized low-density lipoprotein LDL (oxLDL) were not changed [113].