SOS2 and cancer: Although mutated SOS2 has not yet been recognized as a cancer driver, at least 253 mutations in the SOS2 gene (195 missense, 45 synonymous, 12 truncating, and one splice-site) have been detected so far in sporadic tumors (https://www.intogen.org/search?gene=SOS2 (accessed on 20 June 2021)).