Indeed, carriers of the N363S polymorphism of the NR3C1 gene, who have higher sensitivity to glucocorticoids, have a higher waist-to-hip ratio, increased body mass index (BMI), elevated concentrations of cholesterol and triglycerides, lower bone mineral density, and higher prevalence of coronary artery disease independent of weight gain [40,41,42]. Here, NR3C1 is linked to coronary artery disorder.