These include (a) Fc-receptor blockade, (b) neutralization of Abs by idiotypic and anti-idiotypic Abs, (c) blockade of the Fas apoptotic pathway by anti-Fas auto-Abs, (d) regulation of complement components, (e) modulation of cytokine secretion, (f) hindrance of natural-killer cell activity, (g) inhibition of matrix metalloproteinase-9, (h) suppression of NF-kB activation and IkB degradation, (i) G1 cell cycle arrest, (j) prevention of tumor growth, (k) decrease in leukocyte recruitment, (l) attenuation of T-cell stimulation, (m) effects on Ab kinetics, and (n) effects on dendritic cells. Here, FAS is linked to neoplasm.