MAPT and argyrophilic grain disease: Tau pathology involving the microtubule-binding domain (4R) is associated with PSP (progressive supranuclear palsy), CBD (corticobasal degeneration), AGD (argyrophilic grain disease), CTE (chronic traumatic encephalopathy), and GGT (globular glial tauopathy); tau aggregates can be found in the medial temporal lobe, cortex, basal ganglia, subthalamic nucleus, and substantia nigra [4].