EGFR and cancer: On the basis of literature findings on the transactivation of EGFR by IL-1β [21,22,23,24,25,26,27] and the involvement of EGFR in TF expression in other cancer cell types [14,15,16,17,18,19], a Western blot analysis of EGFR phosphorylation at Tyr1068 and Tyr845 in IL-1β-stimulated A549 cells was performed (Figure 3A).