Figure 4a shows that the ATRX and TP53 mutation patterns were similar. Therefore, we compared TERT expression with the ATRX or TP53 mutation status and tumour grade. TERT expression was highly suppressed in patients with ATRX mutation for all histological tumour grades, but not in those with TP53 mutation of G4 (Figure 6b). It indicated that the TERT expression was tightly regulated by ATRX but not TP53 mutation. The gene discussed is ATRX; the disease is neoplasm.