However, although adiponectin showed a decrease in adiponectin, which is one of the major biomarkers related to adipocyte differentiation, in blueberry peel extract [54] and onion peel extract [55], a decrease in adiponectin might cause side effects, such as type 2 diabetes, obesity, and cardiovascular disease in humans [57]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.