In this study, we highlight in retinal cells with an AMD phenotype that VEGF-R2 is dissociated to Cav-1 to activate the Raf–mitogen-activated protein kinase (MAPK)–extracellular signal-regulated kinases 1/2 (ERK1/2) oncogenic signaling pathway. This evidence concerns the gene MAPK3 and age-related macular degeneration.