Moreover, citrate level was found depleted in malignant mesothelioma cells (compared to non-malignant cells) [29], and microRNA-126, which suppresses tumor growth, also restored citrate level through the inhibition of ACLY and the Protein Kinase B (also named Akt), a pathway promoting ACLY activation [29]. Here, AKT1 is linked to malignant mesothelioma.