Indeed, oral gavage of citrate sodium (4 g/kg twice a day) for several weeks (4 to 7 weeks) significantly regressed tumors in various murine models, such as subcutaneously implanted syngeneic pancreatic tumor (Pan02), human lung adenocarcinoma (A549 cells) xenografts in nude mice, Ras-driven lung cancer in genetically engineered mouse (GEM), and breast cancer driven by human epidermal growth factor receptor 2/(Her2/Neu) in GEM [77]. This evidence concerns the gene ERBB2 and breast cancer.