As showed in Table 1, this anti-cancer effect involves various mechanisms such as the inactivation of PFK1, the inhibition of glycolysis and ATP production, and the stimulation of apoptotic cell death by various processes (in particular, the activation of pro-apoptotic proteins and various caspases (2, 3, 8, and 9), and the decreased expression of the two key anti-apoptotic factors, Bcl-xL and Mcl-1 [75,76]). This evidence concerns the gene PFKM and cancer.