COMP and hepatocellular carcinoma: In cancer-associated fibroblasts (CAFs), FOXM1 and its downstream targets are upregulated in several cancers [251] and hepatocellular carcinoma CAFs rely on FOXM1 to activate cartilage oligomeric matrix protein (COMP) gene expression, which eventually increases EMT, invasion, and stemness of hepatocellular carcinoma cells [252].