SLC2A1 and hepatocellular carcinoma: Similarly, FOXM1 knockdown decreased glucose uptake and lactate production in the hepatocellular carcinoma cell line Hep3B, and the overexpression of FOXM1 in the hepatocellular carcinoma cell line MHCC-97H increased glucose uptake and lactate production, but only when appropriate levels of glucose transporter 1 (GLUT1) were present [313].