CTLA4 and colorectal carcinoma: A phase II trial is testing Pembrolizumab combined with the anti-CTLA4 MK1308A in dMMR/MSI mCRC (NCT03179436) and another trial is testing the anti-PD1 Sintilimab in combination with an anti-CTLA4, IBI310, as well as in dMMR/MSI metastatic or locally advanced CRC (NCT04258111).