In the case of Vav1, we found that it plays quite relevant roles in mBSA-induced arthritis, a monoarticular inflammatory model that recapitulates most of the pathobiological features seen in human rheumatoid arthritis, such as leukocyte infiltration, pannus formation, cartilage destruction and synovial tissue hyperplasia [24]. This evidence concerns the gene VAV1 and arthritic joint disease.