It is important to note that the overall balance of GRK5’s effects on the myocardium, i.e., whether it is positive or negative, remains controversial with some studies reporting a beneficial, protective role for GRK5 in the myocardium, including attenuation of atherosclerosis and cardiac nuclear factor (NF)-κB NF inhibition [184,185,186,187], but some others reporting adverse remodeling effects like promotion of fibrosis [188,189]. Here, GRK5 is linked to atherosclerosis.