The rationale behind using the young TDP-43 transgenic mice was to explore whether a subtle (2.3–3-fold) overexpression of TDP-43 represents an additional risk factor in the context of mild repetitive TBI, as well as to observe whether it would predispose and/or trigger more intense neurodegeneration, as observed in the model of stroke [44]. This evidence concerns the gene TARDBP and Stroke.