In a recent study, Kumar et al. [64] found that cytoplasmic TDP-43 accumulation in mice expressing ALS-linked human TDP-43A315T mutant caused marked suppression of mRNA translation for NfL, Nf medium, and α-internexin, resulting in a decrease in the levels of these proteins at 12 months of their age when they exhibited TDP-43 proteinopathy in cortical neurons. Here, TARDBP is linked to amyotrophic lateral sclerosis.