CD4 and neoplasm: Finally, CSF-1R blockade not only influences the TAM presence in the TME but can also promote CD8+ T cell infiltration and/or decrease FoxP3+ Tregs, MDSCs, and CD4+ T cells in tumors, depending on the type of tumor model [23,24,25], which opens a new area of research for investigation of an anti-CSF-1R therapy in tumors with a distinct MHC-I expression.