The presence of two or more of the four major islet autoantibodies (IAbs), targeting insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma antigen 2 (IA-2A), and zinc transport 8 (ZnT8A), is now sufficient to diagnosis presymptomatic stage of T1D and confers a 70% risk of developing clinical T1D within 10 years and a nearly 100% probability of disease manifestation within two decades [2,4]. Here, INS is linked to type 1 diabetes mellitus.