PTGS2 and brain injury: Tu et al. examined the effects of the GLP-1R agonist, liraglutide, in a rat model of subarachnoid hemorrhage (SAH)-induced brain injury, and reported that it attenuated the increases in levels of inflammatory mediators, including cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), TNF-α, and IL-1β [129].